About the role
We are seeking a highly skilled and innovative **Senior Scientist** to lead the development of next-generation molecular diagnostic assays with a focus on **rapid PCR technologies** and **sample preparation workflows**. The successful candidate will drive new assay designs from concepts through feasibility, ensuring scientific rigor, data quality, and regulatory-grade documentation. This role requires deep technical expertise in molecular biology, strong data analysis and interpretation skills, and the ability to design experiments that accelerate product development timelines. The individual will work as part of Nuclein’s Assay Research team, reporting to Nuclein`s Chief Scientist.
**Essential Duties and Responsibilities.**
·Work independently on Nuclein`s assay and chemistry research efforts for the company’s menu test pipeline
·Design, develop, and optimize rapid/fast-cycle PCR and qPCR assays for DNA and RNA targets.
·Lead feasibility and development studies to evaluate assay performance (LOD, linearity, robustness).
·Innovate sample preparation and extraction workflows compatible with automated or integrated molecular platforms.
·Develop statistically sound study designs and analyze large datasets using tools such as JMP, Excel, R, or Python.
·Perform kinetic and efficiency analyses, baseline correction, and melt curve interpretation for assay optimization.
·Interpret experimental results, troubleshoot issues, and propose data-driven solutions.
·Prepare detailed technical reports, development summaries, and design control documentation (per ISO 13485 or FDA guidelines).
·Design and execute experiments and test protocols to demonstrate proof-of-concept and feasibility for new assay oligo designs/formulations/new chemistries.
·Work closely with the company’s Development group, providing integration support for new, and existing assays
·Able to analyze and document experimental data/results; write detailed project plans and feasibility reports
·Investigate field and customer complaints/issues for on-market Nuclein assays
**Education, Qualifications, and/or Experience.**
·Ph.D. in a relevant scientific discipline, such as molecular biology, chemistry or a related field or equivalent years of education and experience combined, minimum of 7 years industrial experience.
·Expertise in quantitative PCR optimization, nucleic acid extraction from biological specimens, or microbiological culture preferred.
·Experience with microfluidic or cartridge-based molecular systems.
·Background in qPCR data processing, automation scripting, or DOE (Design of Experiments).
·Proficient with statistical analysis methods applicable to molecular assay development.
·Strong analytical and problem-solving skills, with the ability to interpret complex data sets and draw meaningful conclusions.
·Excellent communication skills, both written and verbal, with the ability to effectively present scientific findings to internal and external stakeholders.
·Collaborative mindset with the ability to work effectively within multidisciplinary teams.
**Physical Requirements.**
·Repetitiveuse
·Weightlifting: Up to 50 lbs.
·Position: Sitting and standing
·Use of PPE may be required in laboratory areas