Overview
Tyra Biosciences, Inc. is seeking a Sr. Manager, Sample Management that is a highly organized and scientifically driven professional to lead and support clinical sample management for small-molecule drug development programs.
The Sr. Manager, Sample Management will be responsible for ensuring high-quality sample collection, processing, storage, shipment, reconciliation, archival, and final disposition of PK, PD, and biomarker samples for multiple programs and across global trials. This individual will also assist with vendor oversight, analysis plans, as well as data integrity checks and data transfer logistics. The candidate will be an integral member of study teams and will ensure sample management compliance with study protocols and quality standards (e.g., ICH GCP guidelines). The ideal candidate will bring strong technical expertise, attention to detail, and the ability to operate effectively in dynamic environments.
Job Responsibilities
- Plans, coordinates and oversee all operational activities for the collection, handling, shipment, storage, and delivery of biomarkers, pharmacogenetics, and pharmacokinetic samples within Phase I to III clinical trials, while being simultaneously assigned to multiple global trials.
- Develop Study Sample Management Plans to document cross-functional agreements on the lifecycle and reconciliation plan for each sample type.
- Maintain vendor relationships and readiness through regular interactions, correspondence, and site visits (where appropriate).
- Maintain accurate records of all sample-related activities, including deviations and corrective actions.
- Provide input for sample collections in key documents such as clinical study protocols/synopses, lab manuals, and informed consent forms to ensure the logistical feasibility of the sample collection strategy.
- Participate in vendor selection, management and oversight, and assist with budget, quotes, purchase order, and invoice tracking/approval.
- Train study team members and investigational site personnel in biosample handling requirements.
- Supports the study team with the submission to IRBs and ECs and responds to IRB/EC requests.
- Accountable for ensuring that the data received is consistent with the collection and assay plans and protocol.
- Report on status including reconciliation against consent.
- Ensure sample management records are always inspection-ready
- Build relationships and foster excellent collaboration and communication with internal and external stakeholders and partners
- Contributes to process improvement initiatives when required
Minimum Requirements
- Bachelor’s degree in life sciences with a minimum of >5 years of pharmaceutical/biotech industry experience, specifically in clinical sample management and oversight
- Sound understanding of clinical samples and their life cycle management is essential
- Knowledge of regulatory guidelines (e.g., ICH-GCP)
- Proven ability to communicate and collaborate effectively within and across teams
- Self-motivated team player who works effectively in a fast-paced environment to meet deadlines, with a can-do attitude and persistent attention to detail
- Excellent communication, influencing, collaboration, organizational, and problem-solving skills
Pay Range and Benefits
Base Salary Range : $152,352 - $168,775 USD
Individual compensation will be determined based on factors such as work location, skills, education, training, and experience.
What we offer US-based Employees:
- Competitive base, bonus, new hire and ongoing equity packages
- The starting compensation range(s) for this role is for a full-time employee (FTE) basis
- Benefit offerings are subject to the terms and conditions of the applicable plans in effect at the time and may require enrollment
- Employer-paid Medical, dental, and vision insurance
- Employer-paid life insurance, AD&D, short-term disability, long-term disability, and EAP coverage
- 401(k) Plan with a fully vested company match 1:1 up to 4% of contributions
- Employee Stock Purchase Plan
- 14 -18 paid holidays, including office closure between December 25th and January 1st
- Flexible vacation
- Sick time
- Fitness Program
- Get Outdoors Program
- Paid parental leave benefit
- Tuition assistance
