About the Role
We are looking for a motivated, hands-on Senior Associate Scientist to support our protein science team in developing molecular glue therapies. This role focuses on the execution of biochemical experiments and protein production to enable targeted protein degradation programs. Working under the guidance of senior scientists, you will contribute to the discovery and preclinical development of transformative medicines in a fast-paced, collaborative environment.
What You’ll Do
- Execute purification protocols for recombinant E3 ligases and other disease-relevant proteins using AKTA FPLC systems.
- Perform and troubleshoot established biochemical and cell-based assays (HTRF, AlphaScreen, etc.) to support lead discovery and SAR studies.
- Process and organize experimental data for review by project teams, ensuring high accuracy and attention to detail.
- Collaborate daily with biologists and chemists to provide the high-quality protein reagents needed to meet project milestones.
- Maintain meticulous notebooks and contribute to general lab organization and reagent inventory.
- Support the implementation of new biochemical techniques and laboratory automation workflows.
What We’re Looking For
- B.S. or M.S. in Biochemistry, Molecular Biology, or a related field, with a minimum of 9+ years of relevant industry experience for candidates with a B.S., or 6+ years for candidates with an M.S.
- Hands-on proficiency in protein expression (bacterial, insect, or mammalian systems) and multi-step protein purification.
- Direct experience operating AKTA FPLC systems and performing protein characterization (SDS-PAGE, Western Blot, SEC).
- Experience performing plate-based high-throughput biochemical assays (e.g., DSF, luminescence, or FRET-based) and basic cell culture maintenance.
- Experience with HTS-enabling technologies (eg. liquid handlers, compound dispensers)
- Strong organizational skills with the ability to manage multiple tasks and experimental timelines simultaneously.
- A collaborative team player who is eager to learn new technologies in the targeted protein degradation (TPD) space.
- Effective communication skills and a rigorous approach to data integrity.
What we offer:
- Industry-competitive compensation
- Annual target bonus
- Stock options
- 401K plan
- Career advancement opportunities
- Monthly town halls to share business and scientific updates
Work Hard, Stay Well
- Comprehensive medical, dental, and vision plans for employees and their dependents
- Health and Dependent Care FSA and HSA Plan with a monthly Neomorph contribution
- Employee Assistance Program
- 10 holidays + Winter Shutdown + 3 weeks of vacation time with additional accruals after 2nd year of employment, separate sick leave.
- Supplemental pay for Pregnancy Disability Leave
- Paid Parental Leave for employees with a newborn child or a child placed with them for adoption or foster care
Lifestyle
- Casual work environment
- Volunteer days off each year to spend time contributing to causes you care about
- Flexible work schedule
- Access to a state of the art gym
- Onsite space to store your bicycle (or surfboard)
Have Fun!
We believe in work/life balance and Fun is at the core of our Core Values. In addition to department and company happy hours, we have regular company-wide and department lunches and social events (ie Padres games, summer picnic, holiday party, bring your kids to work day).
About Us:
Neomorph is a venture-backed biotechnology company solving critical problems in human health through the discovery and development of innovative new medicines against ‘undruggable targets’. Our team is comprised of industry leading experts in protein degradation and molecular glues who have a track record of ground-breaking discoveries in the field. We are committed to leadership in advancing the science and technology of molecular glue drug discovery, while prosecuting a pipeline of projects through clinical development. Our patient-first, science-driven approach is complemented by our dedication to a supportive and collaborative work environment.
Neomorph is headquartered in San Diego, California.
Neomorph is committed to pursuing and hiring a diverse workforce and is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment and will not be discriminated against on the basis of any characteristic protected by applicable federal, state or local law.
