Senior Scientist/Principal Scientist, Quantitative Pharmacology (Contractor)

Legend Biotech is seeking Senior Scientist/Principal Scientist, Quantitative Pharmacology (Contractor) as part of the Research & Early Development team based in Somerset, NJ. Role Overview The position seeks a highly motivated and experienced quantitative pharmacologist to lead modeling and simulation efforts in support of gene and cell therapy products, with a focus on QSP and popPK modeling (Prior cell and gene therapy experience preferred). Contract Duration: 12 Months Key Responsibilities * Lead QSP and popPK modeling activities across preclinical and clinical development stages. * Play a pivotal role in shaping clinical pharmacology strategies, supporting regulatory submissions, and driving innovation in model-informed drug development (MIDD). * Develop and apply mechanistic models to understand disease pathways, drug mechanisms, and patient variability. * Conduct simulations to support dose selection, trial design, and exposure-response analyses. * Collaborate cross-functionally with R&D, clinical, regulatory, and biostatistics teams. * Author and review clinical pharmacology sections of regulatory documents (e.g., INDs, NDAs). * Contribute to scientific publications and conference presentations. Requirements * R&D, Preclinical development, Clinical, CMC and regulatory * MS/PhD/Pharm D in Pharmaceutical Sciences, Clinical Pharmacology, Applied Mathematics, Biomedical Engineering, or related quantitative discipline. * 7+ years with MS degree or 3+ years with PhD/Pharm D degree of working experience in quantitative pharmacology or pharmacometrics in pharmaceutical companies or CRO companies (Job titles will be decided per applicant’s working experience) * Have strong execution ability * Strong independent scientific research ability, logical thinking, and coordination/problem-solving skills * Have clear written and oral communication skills * Have a good team spirit * Demonstrated expertise in QSP and popPK modeling, including proficiency with tools such as NONMEM, R, MATLAB, Monolix, etc. * Deep understanding of PK/PD principles, translational medicine, and the role of quantitative pharmacology and model-informed drug development (MIDD) in clinical trials and drug development. * Demonstrated ability and experience in applying modelling and simulation approaches to enable rational and efficient preclinical and clinical drug development. * Familiar with regulatory requirements and guidelines of clinical pharmacology. * Good project management skills, and the ability to collaborate with other departments and manage with internal and external partners. * Proven track record of scientific contributions through publications or presentations. * Good personality, honest and trustworthy. * Physically and mentally healthy, love life.