Senior Scientist, Medicinal Chemistry, Integrated Drug Discovery

Job title

Senior Scientist, Medicinal Chemistry, Integrated Drug Discovery

• Location: Cambridge, MA

About the job

An accomplished synthetic organic and medicinal chemist, with a track record of impactful project contributions in design and synthesis. Join the engine of Sanofi’s mission — where deep immunoscience meets bold, AI-powered research. In R&D, you’ll drive breakthroughs that could turn the impossible into possible for millions.

About Sanofi:

We’re an R&D-driven, AI-powered biopharma company committed to improving people’s lives and delivering compelling growth. Our deep understanding of the immune system – and innovative pipeline – enables us to invent medicines and vaccines that treat and protect millions of people around the world and are supported and enhanced through our diverse portfolio of medical device and diagnostic products. Together, we chase the miracles of science to improve people’s lives.

Main Responsibilities:

• Design and synthesize small molecule targets to drive programs to clinical candidate nomination.
• Use reaction and reagent databases to select effective methods/routes to maximize productivity and provide solutions to complex multi-step synthetic problems.
• Prepare and characterize high purity target compounds and intermediates to meet aggressive project timelines.
• Proficiency with the use of analytical techniques for structural characterization and ability to interpret complex NMR spectra.
• Register compounds in corporate database and maintain notebooks according to SOP.
• Champion new chemistry techniques, reagents and methodology in discovery chemistry and participate in group/lab responsibilities.
• Understand project SAR, adapt and prioritize work proactively based on emerging data.
• Interpret biological data (DMPK, pharmacology, safety) to contribute to project advancement.
• Ability to work independently, proactively and collaboratively with other team members to design compounds to address key issues.
• Dedication to lifelong learning.
• Understand and articulate the scientific rationale of the project to other scientists.
• Provide formal and informal mentoring to junior staff members.
• Determine the relevance of patent search results and assess the patentability of new targets. Assist with filing patent applications by reviewing claims and providing experimental data.
• Actively participate in medicinal chemistry discussions communicating own science in a clear and precise manner; proactively raise issues which positively influence the direction of program.
• Communicate and interact with other staff members in a professional and courteous manner.
• Operate in the lab in a safe and efficient manner according to HSE guidelines and adhere to all mandatory company compliance requirements.
• Adapt to changes and challenges in a productive and professional manner.
• Act as an ambassador for the department and attend appropriate scientific meetings to stay up to date with current literature and industry direction.
• Experience in Induced Proximity Modalities preferred

About you

Education & Experience:

• Bachelor’s Degree in chemistry or related field with minimum 7 years of relevant research experience in an academic or biopharmaceutical setting OR
• Master’s Degree with minimum 4 years of relevant research experience in an academic or biopharmaceutical setting OR
• PhD with minimum 2 years of relevant research experience in an academic or biopharmaceutical setting.
• Deep knowledge of organic chemistry and a growing understanding of medicinal chemistry principles.

Why choose us?

• Bring the miracles of science to life alongside a supportive, future-focused team.
• Discover endless opportunities to grow your talent and drive your career, whether it’s through a promotion or lateral move, at home or internationally.
• Enjoy a thoughtful, well-crafted rewards package that recognizes your contribution and amplifies your impact.
• Take good care of yourself and your family, with a wide range of health and wellbeing benefits including high-quality healthcare, prevention and wellness programs and at least 14 weeks’ gender-neutral parental leave.
• Be part of a pioneering biopharma company that engages patients early in drug development and uses their insights to design studies that reflect real-world needs.
• Help improve the lives of millions of people globally by making drug development quicker and more effective.
• Work at the forefront of drug discovery, harnessing cutting-edge AI, data, and digital platforms to push the boundaries of science.