About Adicet Bio
Adicet Bio, Inc. is a clinical stage biotechnology company discovering and developing allogeneic gamma delta T cell therapies for autoimmune diseases and cancer. Adicet is advancing a pipeline of “off-the-shelf” gamma delta T cells, engineered with chimeric antigen receptors (CARs), to facilitate durable activity in patients. For more information, please visit our website at https://www.adicetbio.com.
Senior Research Associate – Scientist II, Molecular Biology & Viral Vector Platforms
Contract Duration: One year
Why this matters:
This role accelerates cell and genome therapy research by enabling reliable generation, characterization, and improvement of lentiviral vectors used in discovery and preclinical studies.
The Opportunity
We are seeking a highly motivated Senior Research Associate / Associate Scientist (BS/MS) to advance lentiviral vector research with some early process development. This is a 100% bench-based, hands-on laboratory role focused on running, troubleshooting, and improving upstream and downstream LVV workflows to enable discovery and preclinical studies.
Hands-on, bench role : This position is primarily lab-based and focuses on molecular biology, library design/generation for screening mammalian/phage display or related, lentiviral vector production, and T cell / immune cell workflows. Success in this role requires strong experimental execution, troubleshooting, and clear ELN documentation.
Key Responsibilities
- Design, build, and QC DNA constructs and variant libraries for screening (e.g., mammalian/phage display), including cloning strategy and library design influenced by structure-function analysis.
- Produce, titer, and QC lentivirus from HEK293T or derivatives; optimize transfection and harvest conditions to improve yield/quality.
- Perform mammalian tissue culture (maintenance, banking, transfection/transduction) in BSL-2; support scale-up as needed (cell factories and/or single-use bioreactors, where applicable).
- Execute immune cell workflows as applicable (PBMC/T cell isolation, activation, gene delivery, expansion) and support functional characterization.
- Run qPCR/RT-qPCR and multi-parameter flow cytometry; analyze results, troubleshoot, and recommend next experiments.
- Maintain rigorous ELN documentation and follow EHS/BSL-2 practices for viral vectors and human-derived materials.
Leveling will align with experience （Senior Research Associate through Scientist)and demonstrated hands-on capability in molecular biology, library generation/screening, lentivirus, and cell culture/immune cell workflows.
Qualifications
Minimum Qualifications
- B.S. + 4 years, M.S. + 2 years, or Ph.D. + 1–2 years （or equivalent） in Molecular Biology, Cell Biology, Immunology, Bioengineering, Biochemistry, or related field.
- Strong molecular cloning and nucleic-acid workflows (vector design, Gibson/In-Fusion, plasmid prep, PCR/qPCR) with independent troubleshooting.
- Library design/build for screening or display (mammalian/phage or related) and support of selection/screen workflows.
- Lentivirus production in HEK293T/293T (transfection, harvest) plus titering/QC (qPCR/ddPCR, p24, and/or functional assays).
- Strong mammalian tissue culture (aseptic technique, expansion, banking) and comfort in BSL-2.
- High experimental rigor, clear ELN documentation, and ability to run multiple experiments in parallel.
Preferred Qualifications
- T cell activation, lentiviral transduction, expansion, and flow cytometry-based phenotyping/functional readouts.
- NGS-enabled library readouts (barcoding strategies, sample prep coordination, and basic analysis partnership).
- Viral vector scale-up/scale-down (cell factories, wave, or single-use bioreactors) and/or downstream handling (clarification/filtration, UF/DF, TFF
***This role is open to individual contractors only. Recruitment agencies: please do not contact us or submit candidates.***
