Senior Research Associate, Protein Sciences

THE ROLE

We are seeking passionate and creative individuals who want to contribute to Septerna’s mission to utilize innovative drug discovery technologies for GPCR targets. The ideal candidate will have experience in protein purification using a variety of methods including fast-performance liquid chromatography (FPLC), microscale purification, and magnetic bead-based purification.

The chosen candidate will be working in a collaborative team contributing to medium and large-scale protein production and characterization for use in structural biology, biophysics, and small molecule drug discovery. This position offers the unique opportunity to join an innovative well-funded biotechnology company and to contribute to its long-term success.

The position is based in South San Franscisco, CA. Title and compensation commensurate with experience.

40 hrs/week, one year contract role

Responsibilities

• Perform as a hands-on protein production associate to help fully enable Septerna’s Native Complex™
• Carry out medium and large-scale protein production utilizing a variety of techniques including FPLC, gravity flow, microscale, and magnetic bead purification
• Qualify proteins utilizing techniques including SDS-PAGE, flow cytometry, fluorescent SEC, and DSF.
• Work collaboratively with Discovery Biology teams in ensuring proper prioritization and timelines of cell culture requests.
• Laboratory notebooking, data analysis and documentation.

Qualifications

• BS with 4+ years of hands-on relevant experience in a biotechnology or pharmaceutical setting.
• 2+ years demonstrated expertise in large-scale protein purification
• Experience with affinity chromatography, ion-exchange chromatography, size exclusion chromatography, and SDS-PAGE
• Prior experience with basic protein quality control techniques (SDS-PAGE, fSEC, DSF) is desirable.
• Ability to write and follow standard operating procedures to ensure high-quality protein reagent production.
• Strong skills in carrying out multiple simultaneous projects to ensure delivery of reagents with appropriate prioritization and timelines
• Demonstrated experience working collaboratively in a team-oriented environment
• Clear and effective verbal and written communication skills