Scientist II – Oligonucleotide Process Development, Manufacturing Development and Scale-Up
Research DevelopmentBachelor RequiredMid Level
Working at Abbott
At Abbott, you can do work that matters, grow, and learn, care for yourself and your family, be your true self, and live a full life. You’ll also have access to:
* Career development with an international company where you can grow the career you dream of.
* Employees can qualify for free medical coverage in our Health Investment Plan (HIP) PPO medical plan in the next calendar year.
* An excellent retirement savings plan with a high employer contribution.
* Tuition reimbursement, the [Freedom 2 Save](https://www.abbott.com/corpnewsroom/strategy-and-strength/tackling-student-debt-for-our-employees.html) student debt program, and [FreeU](https://www.abbott.com/corpnewsroom/strategy-and-strength/college-degree-for-free-its-possible-with-freeu.html) education benefit - an affordable and convenient path to getting a bachelor’s degree.
* A company recognized as a great place to work in dozens of countries worldwide and named one of the most admired companies in the world by Fortune.
* A company that is recognized as one of the best big companies to work for as well as the best place to work for diversity, working mothers, female executives, and scientists.
The Opportunity
The Scientist II role works out of our Carlsbad, CA location in the Infectious Disease Division at Abbott. We’re empowering smarter medical and economic decision-making to help transform the way people manage their health at all stages of life. Every day, more than 10 million tests are run on Abbott’s diagnostics instruments, providing lab results for millions of people.
What You’ll Work On
We are seeking an Oligonucleotide Scientist with responsibilities spanning Process Development, Manufacturing Development, and Scale-Up of solid-phase oligonucleotide synthesis. In this role, you will execute, research, develop and optimize oligonucleotide processes across the full development lifecycle — from early feasibility runs through process characterization, tech transfer and scale-up. You will work hands-on with automated synthesizers, develop and refine synthesis cycles, troubleshoot complex chemistries, and drive scale-up from nano-gram process development to micro/milli-gram scale-up. This is a high-impact role for a scientist who enjoys solving problems at the intersection of organic chemistry, analytical science, and process engineering. The scientist will also Independently develop data presentations for use within organization.
* Design and execute solid-phase oligonucleotide synthesis on automated synthesizers (e.g., ÄKTA Oligosynt, ÄKTA Pilot 100, GE/Cytiva flow-through platforms) using phosphoramidite chemistry.
* Develop, optimize, and document synthesis cycles, including coupling, capping, oxidation/sulfurization, and detritylation steps, and tune cycle parameters (reagent equivalents, contact times, flow rates) for each scale and chemistry.
* Support scale-up from process development (PD) to engineering and GMP production batches, including selection of solid supports (CPG, polystyrene, UnyLinker), columns (e.g., SYC, FineLINE), and reagent footprints.
* Synthesize complex modified oligonucleotides, including phosphorothioate (PS) backbones, 2′-OMe, 2′-MOE, LNA, and other relevant modifications.
* Characterize crude and purified product by analytical UPLC, IEX-HPLC, and RP-HPLC, and LC/MS; interpret mass spectra to identify and quantify related impurities (n−1, n+1, depurination, longmers, shortmers, branched species, oxidation/sulfurization products).
* Troubleshoot synthesis failures and impurity profiles, drive root-cause investigations, and implement process improvements.
* Author and review technical documents — protocols, batch records, development reports, deviation investigations, and tech-transfer packages.
* Partner cross-functionally with Analytical Development, Downstream Processing/Purification, Quality, Manufacturing, and Regulatory teams.
* Maintain a safe, clean, and compliant lab environment in accordance with company SOPs and applicable cGMP/ICH guidelines.
Learn more about our health and wellness benefits, which provide the security to help you and your family live full lives: [https://abbottbenefits.com/](http://www.abbottbenefits.com/pages/candidate.aspx)
Follow your career aspirations to Abbott for diverse opportunities with a company that can help you build your future and live your best life. Abbott is an Equal Opportunity Employer, committed to employee diversity.
Connect with us at [abbott.com](https://www.abbott.com/), on LinkedIn at [https://www.linkedin.com/company/abbott-/](https://www.linkedin.com/company/abbott-/), and on Facebook at [https://www.facebook.com/AbbottCareers](https://www.facebook.com/AbbottCareers).
The base pay for this position is
$85,600.00 – $156,000.00
In specific locations, the pay range may vary from the range posted.
Abbott is about the power of health. For more than 135 years, Abbott has been helping people reach their potential — because better health allows people and communities to achieve more. With a diverse, global network serving customers in more than 160 countries, we create new solutions — across the spectrum of health, around the world, for all stages of life. Whether it’s next-generation diagnostics, life-changing devices, science-based nutrition, or novel reformulations, we are advancing some of the most innovative and revolutionary technologies in healthcare, helping people live their best lives through better health.
The people of Abbott come to work each day with relentless energy, enthusiasm and a promise to enhance the health and well-being of millions of people. They push the boundaries to help manage and treat some of life’s greatest health challenges.
We invite you to explore opportunities at Abbott , to see if your talents and career aspirations may fit with our openings. An equal opportunity employer, Abbott welcomes and encourages diversity in our workforce.
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