Scientist II, Downstream Viral Vector Process Development

Overview

GeneFab is seeking an experienced Downstream Process Development Scientist/Lead focused on viral vector purification (AAV and Lentiviral) for in vivo gene therapy. It is a technical, project-based role within a CRDMO environment that balances hands-on process optimization with cross-functional leadership and client-facing responsibilities.

Responsibilities

• Design, optimize, and scale-up downstream processes for the purification of viral vectors, with a focus on in vivo gene therapy products and lentiviral vectors.
• Execute experimental plans, analyze data, and provide insightful recommendations to improve process efficiency, yield, and product quality.
• Collaborate with cross-functional teams, including Upstream Process Development, Analytical Development, and Manufacturing, to ensure seamless integration of processes.
• Troubleshoot and resolve technical challenges in downstream processes, ensuring robust and scalable solutions.
• Present internally and to client with project status updates
• Stay abreast of industry trends, emerging technologies, and regulatory guidelines to contribute to the continuous improvement of processes and compliance.
• Provide direction and leadership to development associates as the team expands.

Qualifications

• Ph.D. or Master’s degree in Chemical Engineering, Biochemical Engineering, Biotechnology, or related field with a minimum of 3 years (Ph.D.) or 5 years (Master’s) of relevant industry experience
• Proven expertise in downstream process development for viral vectors, with a focus on AAV and lentiviral vectors.
• Hands-on experience with chromatography, filtration, TFF and other downstream processing techniques.
• Strong analytical and problem-solving skills, with the ability to interpret complex data sets.
• Excellent communication skills and the ability to work collaboratively in a team environment.
• Knowledge of regulatory requirements and quality standards related to biopharmaceutical manufacturing.
• Experience with formulation science preferred