Scientist I, ASO Process Development and Manufacturing

About This Role:

We are seekinga highly motivated and creative individual to join our Oligonucleotide Chemical Development team as a Scientist I. This role is an exciting opportunity to develop robust processes for the synthesis of oligonucleotides, contributing significantly to both clinical and commercial therapeutics. You will gain hands-on experience in designing and developing manufacturing processes, working closely with our development and manufacturing teams. Your efforts will enhance process robustness, productivity, and impurity control, bringing substantial value to our work in oligonucleotide synthesis. As part of the larger Biogen structure, your contributions will play a pivotal role in advancing our scientific endeavors and impacting patient outcomes.

What You’llDo:

• Collaborate with development and manufacturing teams to design and conduct laboratory experiments to optimize synthesis processes.
• Perform ASO pilot-scale syntheses to support preclinical studies.
• Accurately record experimental procedures and data.
• Communicate research results effectively through writing reports and presenting in meetings.
• Engage in CMC activities, including authoring CMC sections of INDs.

Who You Are:

You are passionate about exploring novel scientific ideas and eager to play a key role in developing cutting-edge technologies. Your vision aligns with Biogen’s state-of-the-art science in oligonucleotide synthesis, and you have a strong commitment to impacting patient lives positively. You thrive in a collaborative environment and are driven by a desire to innovate and contribute to scientific advancements.

Required Skills:

• M.S. with 0-2 years of relevant experience in pharmaceutical or biotech settings.
• B.S with more than 3 years of relevant experience in pharmaceutical or biotech settings.
• Specialization in synthetic organic chemistry, with excellent synthetic skills and a deep understanding of reactivity and reaction mechanisms.
• Ability to work both independently and collaboratively, with effective communication skills in written and oral forms.
• Self-driven, independent thinker, vigorous and thorough in experimentation and data interpretation.

Preferred Skills:

• Experience in nucleoside chemistry or oligonucleotide synthesis.
• Perform synthetic process research and development of drug candidates and conjugates.
• Continuous improvement mindset for research projects and synthesis processes.