Scientist 1, Oligonucleotide Chemist (Synthesis & Purification)

Description

Who We Are

BioMarin is a leading rare disease biotechnology company focused on genetically defined conditions.

Guided by our purpose to develop medicines that make a profound impact on people’s lives, our global teams have delivered a portfolio of therapies since our founding in 1997. Our revolutionary treatments for conditions like achondroplasia (the most common form of dwarfism), PKU (phenylketonuria), CLN2, a form of Batten disease, and a number of forms of MPS (mucopolysaccharidosis) offer new possibilities for patients and families who previously had few, if any, available options. More recently, with the close of the Amicus acquisition, our portfolio has expanded to include therapies for Fabry disease and Pompe disease, expanding our ability to reach more people living with rare genetic conditions.

Our success comes from our unwavering commitment to excellence, our deep understanding of patient needs, our scientific expertise, and our world-class manufacturing capabilities. At the heart of BioMarin is a dedicated team of the brightest minds in the industry working together to deliver innovative therapies to patients and families around the world.

About Worldwide Research and Development

From research and discovery to post-market clinical development, our R&D engine involves all bench and clinical research and the associated groups that support those endeavors. Our teams work on developing first-in-class and best-in-class therapeutics that provide meaningful advances to patients who live with rare diseases.

Overview:

BioMarin is seeking a dedicated and skilled Scientist specializing in oligonucleotide synthesis to contribute to our cutting-edge research and development efforts in nucleic acid-based therapeutics. This role offers a unique opportunity to be part of a dynamic team at the forefront of biotechnology innovation, working on projects that have the potential to transform patient outcomes.

Key Responsibilities:

• Engage actively in project team discussions across the organization, providing subject matter expertise to support the progression of research projects and the development of new methodologies.
• Work synergistically with multidisciplinary teams, including bioconjugation specialists, chemists, and biologists, to drive project success and foster a collaborative research environment.
• Execute oligonucleotide synthesis utilizing automated solid-phase synthesis methodologies to ensure high-quality and reproducibility of synthesized oligonucleotides.
• Conduct purification of synthesized oligonucleotides via high-performance liquid chromatography (HPLC) and other relevant techniques to achieve the desired purity and quality standards.
• Maintain comprehensive and meticulous records of experimental protocols, results, and data analyses, ensuring data integrity and compliance with regulatory standards.
• Contribute to the maintenance of a safe and compliant working environment, adhering to all health and safety regulations and promoting a culture of safety within the laboratory.

Education & Requirements:

• PhD degree in Chemistry with 0-2 years of industry experience or Master’s degree with 8-10 years in the biotech or pharmaceutical industry.

Skills:

• Demonstrated ability to work independently as well as part of a collaborative team environment, with a proactive approach to problem-solving and advancing research programs.
• Strong enthusiasm for scientific research and innovation, coupled with excellent organizational skills and the ability to manage multiple tasks and projects simultaneously
• Commitment to maintaining up-to-date knowledge of advancements in oligonucleotide chemistry and related fields, with a willingness to engage in ongoing professional development.
• Expertise in solid-phase oligonucleotide synthesis and purification, with a strong track record of successful project outcomes.
• Excellent written and verbal communication skills, with the ability to effectively present data and findings to both technical and non-technical audiences.

Work Style:

• This is an onsite daily role in San Rafael, CA.
• This role will have a daily presence in our Research labs executing experiments.

This position represents an exciting opportunity to contribute to BioMarin's mission of developing innovative therapies for patients with serious and life-threatening conditions. We look forward to welcoming a passionate and skilled oligonucleotide chemist to our team.

Note: This description is not intended to be all-inclusive, or a limitation of the duties of the position. It is intended to describe the general nature of the job that may include other duties as assumed or assigned.

Equal Opportunity Employer/Veterans/Disabled

An Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, or protected veteran status and will not be discriminated against on the basis of disability.