Principal Associate Scientist / Scientist - Immunology (Donor Biology)

Company Overview:

Prellis Biologics is a dynamic startup revolutionizing immunology. We develop cutting-edge technologies to unlock the immune system's potential and drive innovation in therapeutic development.

Position Overview:

We're seeking an enthusiastic and talented immunologist to play a pivotal role in advancing our groundbreaking _ex vivo_ immune system platform. You'll collaborate closely with a multidisciplinary team to develop innovative lymph node organoids, design and execute impactful _in vitro_ assays, and contribute your expertise to _in vitro_ immune process development and antigen/antibody biomolecular engineering.

Responsibilities:

• Work collaboratively across teams to illuminate the role of human blood donor biology on the responsiveness in Prellis’ _ex vivo_ immunization system
• Independently analyze and evaluate data including but not limited to immunological population dynamics, mRNA seq data, BCR sequence data, TCR sequence data, as well as monoclonal antibody characteristics to identify human blood donors with high potential of success in Prellis’ _ex vivo_ immunization system.
• Lead human donor blood purchasing, inventory, experimental assignment, and data collection efforts.
• Establish and employ novel techniques to characterize immune cell responses.
• Leverage your knowledge in immunology, cell biology, and molecular biology to contribute intellectually to the development of _ex vivo_ immune processes, antibody responses and to facilitate donor selection.
• Support _ex vivo_ cell culture workflows on occasion.
• Be hands-on in the lab (60-80% of the time) and thrive in a fast-paced environment.

Qualifications:

• PhD in immunology, cell biology, or a closely related field with 1+ years of relevant industry and/or postdoc experience. MSc in immunology, cell biology, or a closely related field with 4+ years of relevant industry experience.
• Deep knowledge of adaptive immunology, in particular B and T cell biology and cell-cell interactions.
• Strong understanding of antibody discovery workflows
• Expertise in experimental design, data analysis, and interpreting complex immunological data sets.
• Extensive immunology lab experience, including flow cytometry (panel design, data acquisition, analysis, troubleshooting).
• Proficiency in primary cell isolation and culture, and in vitro assay development/execution.

Skills & Experience (Preferred):

• Knowledge of immune tolerance, vaccine development, and systems immunology.
• Project management expertise.
• Experience with bioinformatic analysis of proteins and sequences.
• Familiarity with molecular biology techniques.
• Experience developing and implementing laboratory systems.
• Proficiency in FlowJo, and GraphPad Prism software.