Postdoctoral Fellow/ Scientist I, Single-Cell Method Development
Chan Zuckerberg Biohub Network, New York, NY, Onsite
Research DevelopmentPhd RequiredMid Level
Chan Zuckerberg Biohub Network, New York, NY, Onsite
The **Chan Zuckerberg Biohub New York**(CZ Biohub NY, ) is an independent nonprofit research institute that brings together three powerhouse universities - Columbia University, The Rockefeller University, and Yale University - into a single collaborative technology and discovery engine. CZ Biohub NY itself supports some of the brightest, boldest engineers, data scientists, and biomedical researchers to investigate the fundamental mechanisms underlying disease and develop new technologies that will lead to actionable diagnostics and effective therapies. We are guided by our values of scholarly excellence; disruptive innovation; hands-on engineering/hacking/building; partnership and collaboration; open communication and respect; inclusiveness; and opportunity for all.
Diversity of thought, ideas, and perspectives are at the heart of CZ Biohub Network and enable disruptive innovation and scholarly excellence. We are committed to cultivating an inclusive organization where all colleagues feel inspired and know their work makes an important contribution.
The **Laboratory of Immunogenomics** at **CZ Biohub NY** ([www.mahatlab.com](http://www.mahatlab.com)) studies the non-coding regulatory genome to understand and address immune dysfunction in diseases like cancer, autoimmune disorders, and aging. We focus on enhancers—non-coding, highly cell–type–specific transcriptional regulatory elements—and their role in shaping immune responses. We develop and utilize genomic technologies, including bulk and single-cell nascent RNA sequencing, genome editing, immune engineering, and CRISPR-based functional screens in patient biopsies, organoid systems, and mouse models. Through computational analysis integrating machine learning and AI, we map enhancer–gene networks and identify disease-driving elements. Our goal is to advance enhancer-guided precision genomic medicine for diseases involving immune dysfunction.
We are seeking a highly motivated **Postdoctoral Fellow/ Scientist I** to lead the development of a high-throughput adaptation of a newly established single-cell nascent RNA sequencing method (scGRO-seq) and apply it to patient biopsies and organoid models. The role involves designing, optimizing, and benchmarking cutting-edge single-cell genomics workflows, integrating them with perturbation-based assays, and generating datasets that drive transformative insights into immune regulation.
This is a wetlab-based, hands-on position that specifically requires experience in method development and offers the opportunity to develop and implement the assay, conduct perturbation experiments, and oversee data generation. Once the workflow is established, this position will coordinate large-scale data acquisition and collaborate with computational biologists on downstream analyses to deliver actionable translational insights. This role is ideal for a recent PhD with a proven track record in single-cell biology who excels at the intersection of technological innovation and transcription regulation. You will join a highly collaborative team working toward a shared vision at the cutting-edge of single-cell immunogenomics.
The New York, NY base pay for a new hire in this role is Postdoctoral Fellow = $93,000.00, Scientist I = $120,000 - $150,000. This position may be eligible to participate in Biohub's discretionary annual performance bonus program. Bonus eligibility and targets are determined in accordance with Biohub's total rewards philosophy and may vary by role.
We’re thankful to have an incredible team behind our work. To honor their commitment, we offer a wide range of benefits to support the people who make all we do possible.
If you’re interested in a role but your previous experience doesn’t perfectly align with each qualification in the job description, we still encourage you to apply as you may be the perfect fit for this or another role.
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Our mission is to help scientists cure or prevent all disease. At Biohub, we build the technology to help scientists around the world use AI-powered biology to study how cells operate, organize, and work as part of systems to understand why disease happens and how to correct it. With unprecedented scale of compute, AI research and engineering, and state-of-the-art technology for measuring, imaging, and programming biology, Biohub is leading the first large-scale scientific initiative to push the frontier of artificial intelligence for biology.
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