Optical Engineer, Advanced Light Sheet Microscopy
Chan Zuckerberg Biohub Network, San Francisco, CA, Hybrid
Research DevelopmentMaster RequiredSenior
Chan Zuckerberg Biohub Network, San Francisco, CA, Hybrid
Biohub is a 501(c)(3) biomedical research organization building the first large-scale scientific initiative combining frontier AI with frontier biology to solve disease. We build the technology to help scientists around the world use AI-powered biology to study how cells operate, organize, and work as part of systems to understand why disease happens and how to correct it. With our compute capacity, AI research and engineering, and state-of-the-art technology for measuring, imaging, and programming biology, we are enabling scientists worldwide to use AI-powered biology to advance our understanding of human health. Through our multi-dimensional imaging program, we build imaging tools that capture life across scales — from single proteins to whole organisms — revealing how proteins and cells function, communicate, and assemble into living systems. These observations are laying the groundwork for a new generation of AI models that can predict cellular behavior and guide the development of better treatments for widespread diseases. You can learn more about our work [here](https://biohub.org/imaging/). Our work brings together three powerhouse universities - Stanford, UC Berkeley, and UC San Francisco - into a single collaborative technology and discovery engine.
We are a team of passionate individuals powered by technology, guided by scientific research, and driven by collaboration, working toward a mission to cure or prevent all disease.
An overarching goal of the Biohub is to elucidate the complex collective dynamics of self-organizing cellular systems across scales in health and disease. To this end, we design, build, and use[ state-of-the-art light-sheet microscopes](https://www.nature.com/articles/s41592-022-01417-2) to visualize wild-type and perturbed zebrafish embryonic development in living zebrafish as model vertebrate organisms. Lightsheet microscopes are powerful imaging instruments capable of resolving individual cells in 5D (=D+color+time) within entire living specimens. In this position, you will become an integral part of[ Loic Royer](https://twitter.com/loicaroyer)’s[ multidisciplinary team](http://royerlab.org) of computer scientists, optical engineers, and biologists focused on decoding how cells self-organize to build complex tissues, as exemplified by our recent[ work.](https://zebrahub.ds.czbiohub.org/)
We seek an **Optical Engineer, Advanced Light Sheet Microscopy** with strong hands-on engineering skills, experience building and integrating scientific instrumentation, ideally lightsheet microscopes, and solid programming expertise for hardware control and automation. A successful candidate will combine practical advanced optical design and system-building experience with the ability to develop and maintain robust control software for advanced light-sheet microscopes. In this position, you will collaborate with scientists, bioengineers, computer scientists, and biologists to co-design and build our [imaging systems](https://vimeo.com/540518886), optimise our instruments, and design automation of[ time-lapse imaging](https://vimeo.com/799695383) of live specimens.
The San Francisco, CA base pay range for a new hire in this role is $153,000.00 - $191,000.00. New hires are typically hired into the lower portion of the range, enabling employee growth in the range over time. Actual placement in range is based on job-related skills and experience, as evaluated throughout the interview process.
This position may be eligible to participate in our discretionary annual performance bonus program. Bonus eligibility and targets are determined in accordance with our total rewards philosophy and may vary by role.
As we grow, we’re excited to strengthen in-person connections and cultivate a collaborative, team-oriented environment. This role is a hybrid position requiring you to be onsite for at least 60% of the working month, approximately 3 days a week, with specific in-office days determined by the team’s manager. The exact schedule will be at the hiring manager's discretion and communicated during the interview process.
We’re thankful to have an incredible team behind our work. To honor their commitment, we offer a wide range of benefits to support the people who make all we do possible.
If you’re interested in a role but your previous experience doesn’t perfectly align with each qualification in the job description, we still encourage you to apply as you may be the perfect fit for this or another role.
Our mission is to help scientists cure or prevent all disease. At Biohub, we build the technology to help scientists around the world use AI-powered biology to study how cells operate, organize, and work as part of systems to understand why disease happens and how to correct it. With unprecedented scale of compute, AI research and engineering, and state-of-the-art technology for measuring, imaging, and programming biology, Biohub is leading the first large-scale scientific initiative to push the frontier of artificial intelligence for biology.
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