Molecule Steward Lead - Small Molecules

Position Summary

You will lead molecule stewardship for small molecule programs across development and manufacturing. You will partner with discovery, process development, analytics, regulatory, manufacturing and external suppliers. We value collaborative leaders who make clear technical decisions, care for quality, and focus on patient impact. This role offers visible influence across program lifecycles, strong growth opportunities, and the chance to help GSK unite science, technology and talent to get ahead of disease together.

This role will provide YOU the opportunity to lead key activities to progress YOUR career. These responsibilities include some of the following:

• Lead technical stewardship for a portfolio of small molecule programs from candidate selection through commercial lifecycle.
• Define and maintain product control strategies, lifecycle plans and technical deliverables.
• Coordinate cross-functional teams on technology transfers, process performance qualification, and ongoing process verification.
• Oversee technical risk assessments and deliver mitigation plans for quality, supply and regulatory readiness.
• Provide hands-on technical leadership for investigations, troubleshooting and major change programs across sites and suppliers.
• Mentor and develop the molecule stewardship team and build strong relationships across the network.

Responsibilities

• Own end-to-end technical strategy and decision points for assigned small molecule assets.
• Translate scientific and analytical data into clear, actionable guidance for program teams and stakeholders.
• Ensure data integrity, documentation and evidence support for regulatory submissions and inspections.
• Drive alignment across sites, contract manufacturers and internal teams to ensure consistent product performance.
• Lead Product Technical Lifecycle Team activities and yearly robustness reviews to identify and resolve risks.
• Share best practices for characterization, stability strategies and analytical approaches to improve product robustness.

Why You?

This role is based in the United States and offered as a hybrid role. You will combine on-site collaboration with flexible remote working to meet team and program needs. You will work in a fast-paced, collaborative environment where your technical leadership will shape program outcomes. We welcome people who are accountable, inclusive and focused on delivering quality for patients.

Basic Qualification

We are seeking professionals with the following required skills and qualifications to help us achieve our goals

• Bachelor’s degree in chemistry, pharmaceutical sciences, chemical engineering or related field. Advanced degree preferred.
• At least 8 years’ experience in small molecule development, analytical development, process development or related area.
• Demonstrated experience in molecule stewardship, technology transfer or product lifecycle management for small molecules.
• Experience leading cross-functional teams and making technical decisions in a matrix environment.
• Knowledge of global regulatory expectations for pharmaceutical development, manufacturing and quality.
• Experience managing technical aspects of investigations, deviations and corrective actions.

Preferred Qualification

If you have the following characteristics, it would be a plus

• Master’s or PhD in a relevant discipline.
• Direct experience with technology transfer to multiple sites and with contract manufacturing organizations.
• Experience designing stability programs and analytical characterization strategies for small molecules.
• Familiarity with risk-based approaches and project management tools.
• Proven track record developing technical talent and leading diverse teams.
• Comfortable working across time zones and with cross-cultural, matrixed teams.

Apply now

If this role feels like a fit, please apply and tell us how your experience will help move safe, effective small molecule medicines forward. We look forward to hearing from you.

#LI-GSK

Skills

CMC Strategy, Data-Driven Decision Making, Data Integrity, Debate Moderation, Digital Fluency, GxP Regulations, Lean Management, Problem Solving, Process Optimization, Project Leadership, Risk Awareness, Scientific Writing, Technology Transfer

The US annual base salary for new hires in this position ranges from $200,250 to $333,750. The US salary ranges take into account a number of factors including work location within the US market, the candidate’s skills, experience, education level and the market rate for the role. In addition, this position offers an annual bonus and eligibility to participate in our share based long term incentive program which is dependent on the level of the role. Available benefits include health care and other insurance benefits (for employee and family), retirement benefits, paid holidays, vacation, and paid caregiver/parental and medical leave. If salary ranges are not displayed in the job posting for a specific country, the relevant compensation will be discussed during the recruitment process.

French Salary Range / Fourchette salariale – France EUR 0 to EUR 0The annual gross base salary range for new hires in this position is listed above for each applicable location. These ranges take into account a number of factors including the candidate’s skills, experience, education level and the market rate for the role. In addition, this position may offer an annual bonus and eligibility to participate in our share based long term incentive program which is dependent on the level of the role. More detailed information on the total benefits package will be supplied during the recruitment process. This role is available for applicants from multiple locations, and therefore salary ranges for certain locations are also shown. Salary ranges for other locations are shown because some markets have pay transparency laws that require salary information on job postings, and those locations are potential job sites for this role. If salary ranges are not displayed in the job posting for a specific location or country, the relevant compensation will be discussed during the recruitment process. Please note salaries vary by country based on the candidate’s skills, experience, education level and the market rate for the role. Offers are typically made within the advertised range based on the candidate’s skills, experience and qualifications, with the upper end generally reserved for highly experienced candidates or other exceptional circumstances aligned with these criteria.

Please visit [_GSK US Benefits Summary_](http://us.gsk.com/media/7992/ustrataglance-jobpostings.pdf) to learn more about the comprehensive benefits program GSK offers US employees.

Why GSK?

Uniting science, technology and talent to get ahead of disease together.

GSK is a global biopharma company with a purpose to unite science, technology and talent to get ahead of disease together. We aim to positively impact the health of 2.5 billion people by the end of the decade, as a successful, growing company where people can thrive. We get ahead of disease by preventing and treating it with innovation in specialty medicines and vaccines. We focus on four therapeutic areas: respiratory, immunology and inflammation; oncology; HIV; and infectious diseases – to impact health at scale.

People and patients around the world count on the medicines and vaccines we make, so we’re committed to creating an environment where our people can thrive and focus on what matters most. Our culture of being ambitious for patients, accountable for impact and doing the right thing is the foundation for how, together, we deliver for patients, shareholders and our people.

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