Clinical Laboratory Scientist, General Supervisor

About The Role:

10x Genomics is establishing a diagnostics effort to translate our leading single-cell and spatial genomics technologies into impactful clinical applications. This Clinical Laboratory Scientist/General Supervisor position is responsible for the day-to-day execution and oversight of high complexity next-generation sequencing (NGS) testing within a CLIA-certified laboratory. This role ensures the accuracy, reliability, and timeliness of test results while maintaining full compliance with regulatory and quality standards. The General Supervisor provides technical leadership, staff supervision, and operational support to ensure efficient laboratory performance.

What You Will Be Doing:

• Perform and oversee daily laboratory operations for high complexity NGS assays, ensuring adherence to established protocols and quality standards.
• Supervise and provide guidance to laboratory personnel, including training, competency assessment, and performance management.
• Ensure the accuracy and validity of test results through review of quality control, quality assurance, and assay performance metrics.
• Maintain compliance with CLIA, CAP, and other applicable regulatory requirements.
• Assist in the development, validation, implementation, and optimization of NGS assays and workflows.
• Monitor laboratory workflow, turnaround times, and resource utilization to ensure operational efficiency.
• Troubleshoot technical issues related to instrumentation, assays, and data analysis.
• Review and maintain laboratory documentation, including SOPs, validation reports, and quality records.
• Collaborate with laboratory leadership to support continuous quality improvement initiatives.
• Ensure proper maintenance and calibration of laboratory equipment.

To Be Successful in this Role, You Will Need:

• Active California Clinical Laboratory Scientist (CLS) license (or CGMBS/generalist license) meeting CLIA requirements for high-complexity testing
• Bachelor’s degree in chemical, biological, physical, clinical laboratory science, or a related field
• Meets CLIA General Supervisor qualifications under 42 CFR 493.1461, including appropriate education, training, and experience
• Minimum of 2–4 years of experience in high complexity CLIA testing, with demonstrated expertise and experience in NGS technologies.
• Prior supervisory or leadership experience preferred.
• Strong knowledge of CLIA regulations and quality systems.
• Experience with NGS platforms, library preparation, sequencing, and bioinformatics pipelines.

Additional attributes

• Prior experience serving as CLIA General Supervisor
• Startup or high growth laboratory experience
• Background in medical or oncology diagnostics
• Excellent organizational, analytical, and problem-solving skills.
• Strong communication and leadership abilities.