Clinical Histocompatibility Scientist (CHS)

Key Responsibilities

• Perform high‑complexity HLA testing, including:
• HLA typing (NGS, SSP, RT‑PCR platforms)
• HLA antibody screening and identification (FlowPRA, Luminex, SAB)
• Virtual and physical crossmatches
• Analyze, interpret, and document HLA test results in accordance with ASHI standards
• Prepare and process clinical and donor specimens (whole blood, serum, DNA, tissues)
• Operate, maintain, and troubleshoot specialized HLA instruments such as:
• Luminex platforms
• NGS sequencers
• qPCR / amplification instruments
• Flow cytometers
• Perform quality control (QC), proficiency testing (PT), and maintain accurate documentation
• Assist with assay validations, method comparisons, and lot‑to‑lot verifications
• Participate in workflow improvement, troubleshooting, and CAPA activities
• Communicate effectively with team members, supervisors, and clinical partners
• Support training of new staff as needed
• Participate in rotational On-Call duties during weekends and holidays

Qualifications

Minimum Qualifications

• California CLS License _or_ California CHS License

Preferred Qualifications

• One or more years of experience in an ASHI‑accredited HLA laboratory
• Familiarity with HLA testing workflows, including:
• HLA typing
• Flow cytometry crossmatches
• Luminex platforms (One Lambda)
• Experience performing and interpreting SAB assays
• Understanding of virtual crossmatching and transplant matching algorithms
• Experience with LIMS/LIS systems commonly used in HLA labs
• Experience with method validations or data review

Additional Information

Compensation:

• $46-$63/hour

Schedule:

• Full Time, Day Shift, five 8-hour shifts, Tuesday–Saturday OR four 10-hours shifts, Wednesday-Saturday

What we offer:

• Excellent full time benefits including comprehensive medical coverage, dental, and vision options
• Life and disability insurance
• 401(k) with company match
• Paid vacation and holidays