Associate Scientist, Protein Sciences

Description

Associate Scientist, Protein Sciences

Headquarters Location: South San Francisco, CA, Company relocating to Emeryville, CA Fall of 2026

Candidate Location: Onsite for lab work

Travel Required: 5-10%

Reports To: Senior Scientist II

Department: Protein Sciences & Early CMC

Position Type : Full-time, Exempt

About CytomX Therapeutics:

CytomX Therapeutics, Inc. is committed to changing the treatment of cancer with our novel PROBODY® therapeutic platform. Our commitment to transforming lives with safer, more effective therapies is driven by our curiosity and passion for innovation and our belief that by acting with integrity in an honest, respectful, ethical manner, we have the power to change lives. Our workplace embodies collaboration, open communication, celebrating our successes, and holding each other to the highest possible standards. CytomX’s robust and differentiated pipeline comprises therapeutic candidates across multiple treatment modalities including antibody-drug conjugates (“ADCs”), T-cell engagers, and immune modulators such as cytokines. CytomX’s clinical-stage pipeline includes CX-2051 and CX-801. Learn more at [www.cytomX.com](http://www.cytomx.com/).

Who You Are and What You’ll Do:

You are passionate about the life sciences and making a difference for cancer patients, their families, and healthcare providers. You will be responsible for developing protein production and purification strategies to support all discovery PROBODY programs at CytomX, as well as developing analytical methods—including LC-MS—to characterize these novel molecules. Additionally, you will work closely with the Protein Engineering and Research teams to transition therapeutic programs from discovery to clinical development.

Job Responsibilities:

• Develop parallel purification processes for antibodies, bispecifics and cytokines
• Collaborate with discovery, protein engineering and pharmacology to provide therapeutic and reagent proteins of appropriate quality for use in in vitro and in vivo studies.
• Develop production and purification strategies for various PROBODY bispecific formats
• Solving protein purification problems based on scientific principles, current technologies, and personal experience
• Support the lead selection process by developing various analytical, LC-MS and biophysical methods to characterize novel PROBODY molecules.
• Participating in cross-functional discovery supports and effectively communicates information to appropriate groups and protein sciences staff.

Minimum Qualifications:

• PhD in Biochemistry or Protein Chemistry or related discipline OR MS in Biochemistry with 5+ years of experience in the biotechnology or biopharma industry with increasing responsibility
• Expertise in problem solving the protein purification issues is required.
• Expertise in large and small-scale protein purification using AKTA systems, Tecan or Janus liquid handler system is required.
• Expertise in protein characterization assays such as concentration, endotoxin measurement, SDS-PAGE, CE-SDS, SEC-HPLC, RP-HPLC, HIC and IEF are required.
• Hands-on experience in operating HPLC or UPLC instruments is required.
• Experience in developing analytical methods to characterize antibodies, bispecifics and cytokines is required.
• Experience in managing the protein purification workflow is required
• Please note that a presentation of a scientific seminar is required during the interview process

Preferred Qualifications:

• Experience in antibody therapeutics is preferred.
• Expertise in molecular biology techniques such as cloning, sequencing, etc. is desired.
• Hands-on experience in operating various mass spec instruments and associated software for data analysis preferred.
• Expertise in developability assessment of therapeutic biologics molecules is required

How You Will Work:

• Demonstrates collaboration and teamwork. Works well with others and understands that collaboration leads to better results.
• Possesses strong communication skills. Communicates clearly, concisely, and professionally. Listens actively to build understanding.
• Exhibits strong interpersonal skills and self-awareness. Builds and cultivates strong and enduring relationships with others. Acts with humility and understands own strengths and weaknesses.
• Shows continuous improvement and a commitment to self-management and development. Operates with a continuous improvement mindset and continuously seeks to expand own knowledge and capabilities.
• Demonstrates a patient focus. Puts the patient first in actions and decisions taken.

Compensation, Benefits, and So Much More

• The expected salary range for this role based on the primary location for this position in California is $115,000 - $135,000 per year. Offer amounts are determined by factors such as experience, qualifications, geographic location, and other job-related factors permitted by law.
• A great environment where we work collaboratively, leverage each other’s strengths, and work toward a shared vision with our common goals of doing the best thing for patients.
• A robust and enduring approach to your development and career growth fueled by a strong learning curriculum and career guidance that helps you understand how you can grow your career at CytomX.
• A robust and highly competitive total rewards program that helps you achieve your compensation goals while supporting a great work / life balance.

Conditions of Employment

• Background investigations are required for all positions at CytomX, consistent with applicable law.
• This role is not eligible for visa sponsorship.

CytomX’s Commitment to Diversity, Equity, Inclusion, and Belonging (DEIB)

CytomX believes that DEIB helps drive our success, and we encourage candidates from all identities, backgrounds, and abilities to apply. We are an equal opportunity employer committed to building an inclusive, innovative work environment with employees who reflect our values and ultimately, serve our patients. Therefore, in all aspects of the employment process, we provide employment opportunities to all qualified applicants without regard to race, color, religion, sex, disability, age, sexual orientation, gender identity or expression, pregnancy, medical condition related to pregnancy, creed, ancestry, national origin, marital status, genetic information, or military status, or any other protected status in accordance with applicable law.

Further, we are committed to the full inclusion of all qualified individuals. As part of this commitment, we (and the agencies we work with) will assist individuals who have a disability with any warm assistance requests related to employment, including completing the application process, interviewing, completing any pre-employment testing, participating in the employee selection process, and/or to perform essential job functions where the requested accommodation does not impose an undue hardship. If you have a disability and require reasonable accommodation, or need other assistance in applying for or interviewing for this position, please direct your inquiries to Human Resources, at hr@cytomx.com